USB 2.0 Issues

I have disable selective suspend in windows which fixed USB 3.0 disconnects but the 2.0 drps the connection overnight to the usb hard drive like clockwork. System sleep is disabled. Anyone have any thoughts on why this would happen? Is the spinning 2.5 drive just too much for the system to handle overnight?

Running win 10 64

also for reference running server 2016 and 2019 on my other delta's. Currently running win 10 64 with hyperv server 2012.